Jordan Michelle vapes a CBD oil Produced from hemp in the Cannabis World Congress Conference. Spencer Platt/Getty States across the nation — 29 of these, also Washington DC — have legalized medical marijuana.

The American public largely supports the legalization of medical marijuana. At least 84 percent of the public thinks that the medication ought to be legal for medical applications, and recreational marijuana usage is less contentious than ever, together with 61% of Americans in service.

Though some medical advantages of smoking marijuana might be overstated by advocates of marijuana legalization, recent studies have shown that there are valid medical uses for marijuana and powerful reasons to keep on studying the drug’s medicinal applications.

The NIH’s National Institute on Drug Abuse lists clinical uses for cannabis.

There are two active compounds in marijuana which researchers believe have medicinal uses. These are cannabidiol (CBD) — that appears to affect the mind with no high– and tetrahydrocannabinol (THC) — that has pain relieving properties and is mostly responsible for the large.

But scientists say that constraints on marijuana research imply we have large questions about its medicinal properties. Along with CBD and THC, you will find another 400 or so chemical compounds, over 60 of which can be cannabinoids. A number of these might have medical applications. But without more study, we won’t understand the way to make use of these chemicals.

More study would also shed light on the dangers of marijuana. Even though there are valid uses for medicinal marijuana, that doesn’t imply all use is benign. Some research suggests that chronic, heavy users might have diminished learning, memory, and processing rate, particularly if they began regularly using marijuana before age 16 or 17.

For a few of these medical advantages, there’s great proof. For many others, there’s motive to keep on conducting research.

Jennifer Welsh contributed to a previous version of the story.

A medical marijuana show. REUTERS/Jonathan Alcorn.

A recent report from the National Academies of Sciences, Engineering, and Medicine stated there was definitive proof that cannabis or cannabinoids (that can be present in the marijuana plant) may be a successful treatment for chronic pain.

The report stated that’s "undoubtedly the most typical " reason individuals ask medical marijuana.

Medical marijuana is shown in Los Angeles, California, U.S. August 6, 2007. REUTERS/Mario Anzuoni/File Photo.

That exact same report stated that there ‘s equally powerful evidence bud can assist with muscle spasms associated with multiple sclerosis.

Other kinds of muscle spasms react to bud too. People today use medical marijuana to deal with sinus spasms which are untreatable by other, prescribed drugs.

Christopher Furlong/Getty Images.

There’s a reasonable quantity of proof that marijuana does no damage to the lungs, so if you don’t smoke tobacco. 1 study published in Journal of the American Medical Association found that not only does marijuana not impair lung function, it might even improve lung capacity.

Researchers searching for risk factors of coronary disease analyzed the lung functioning of 5,115 young adults within the span of 20 decades. Tobacco smokers dropped lung function with time, but bud users really demonstrated an increase in lung capacity.

It’s possible that the higher lung capacity might be due to carrying a deep breaths while inhaling the medication rather than from a curative compound in the medication.

The smokers at that study simply toked up a couple of times every month, however a recent poll of individuals who smoked marijuana per day for up to 20 years saw no signs that smoking bud harmed their lungs.

The National Academies report stated that there are good studies demonstrating marijuana users aren’t prone to have cancers related to smoking.

Among the most typical reasons that countries permit medical marijuana use would be to deal with and stop the eye disease glaucoma, which raises pressure in the eyeball, damaging the optic nerve and resulting in loss of eyesight.

Marijuana reduces the pressure within the eye, according to the National Eye Institute: "Studies in the early 1970s revealed that marijuana, when consumed, reduced intraocular pressure (IOP) in people with normal stress and those who have glaucoma. "

For the time being, the medical consensus is that bud only enhances IOP for a couple hours, meaning that there isn’t very good evidence for this as a long-term treatment at the moment. Researchers expect that maybe a marijuana-based compound can be manufactured that lasts more.

A number of studies have revealed that cannabidiol (CBD), yet another significant marijuana compound, appears to aid individuals with treatment-resistant epilepsy.

Numerous people have reported that marijuana is the one thing which will help restrain their children’s seizures.

Nevertheless, there harbor ‘t been numerous gold-standard, double-blind research on the subject, so investigators say more information is required before we understand how successful marijuana is.

Charlotte Figi has Dravet’s Syndrome, and her parents are giving her bud to take care of her seizures. CNN/WEED.

Throughout the study for his documentary "Weed," Sanjay Gupta interviewed the Figi household, who handled their 5-year-old daughter utilizing a medical marijuana breed full of cannabidiol and low in THC.

The Figi household ‘s daughter, Charlotte, has Dravet Syndrome, which causes seizures and severe developmental delays.

According to the movie, the medication decreased her migraines from 300 per week to one daily. Forty other kids in the country were using exactly the exact same breed of marijuana to deal with their seizures once the movie was created — and it appeared to be functioning.

The physicians who recommended this therapy said the cannabidiol from the plant interacts with cells to silence the excess activity in the brain which causes those seizures.

Gupta notes, nevertheless, a Florida hospital which specializes in the disease, the American Academy of Pediatrics, along with the Drug Enforcement bureau don’t endorse marijuana as a cure for Dravet or other seizure disorders.

CBD might help stop cancer from spreading, researchers in California Pacific Medical Center in San Francisco reported in 2007.

Other really preliminary studies on brain tumors in mice or cell cultures show that THC and CBD could impede or shrink tumors at the ideal dose, and it is a powerful reason to do further study.

One 2014 study found that marijuana may considerably impede the increase of the sort of brain tumor correlated with 80 percent of malignant brain cancer in people.

However, these findings from cell cultures and creatures don’t automatically indicate the effect will interpret to people — much more investigation is necessary.

Researchers understand that lots of cannabis users have marijuana to unwind, but also that a lot of folks state smoking too much may lead to anxiety. So scientists conducted a research to locate the "Goldilocks" zone: the ideal quantity of marijuana to calm individuals.

Based on Emma Childs, an associate professor of psychiatry at the University of Illinois in Chicago and an author of this research, "we discovered that THC at reduced doses decreased anxiety, whereas higher doses had precisely the contrary impact. "

A couple of puffs was sufficient to assist study participants unwind, but a couple of puffs more begun to amp up stress. But, individuals can respond differently in various scenarios.

Marijuana could have the ability to slow the development of Alzheimer’s disease, a study headed by Kim Janda of the Scripps Research Institute suggests.

The 2006 study, published in the journal Molecular Pharmaceutics, discovered that THC (the active compound in marijuana) slows the formation of amyloid plaques by blocking the enzyme in the brain which makes them. These plaques kill brain cells and are related to Alzheimer’s.

A synthetic mix of CBD and THC appears to maintain memory in a mouse model of Alzheimer’s disease. Another study indicated a THC-based prescription drug called dronabinol managed to decrease behavioral disturbances in dementia sufferers.

These studies have been in very early stages, however, so more study is required.

Clients shop for "Green Friday" deals in the Grass Station bud store on Black Friday at Denver Thomson Reuters.

Marijuana can alleviate debilitating symptoms of multiple sclerosis, according to a study published in the Canadian Medical Association Journal.

Jody Corey-Bloom analyzed 30 multiple sclerosis patients with painful contractions in their muscles. These patients didn’t respond to other therapies, but after smoking marijuana for a couple of days, they reported they were in significantly less pain.

The THC in marijuana appears to bind to receptors at the nerves and muscles to alleviate pain.

Treatment for hepatitis C disease is unpleasant: unwanted side effects include tiredness, nausea, muscle aches, loss of appetite, and depression. Those side effects may last for weeks, and lead many folks to discontinue their therapy course early.

However a 2006 research from the European Journal of Gastroenterology and Hepatology discovered that 86 percent of individuals using marijuana successfully finished their Hep C treatment. Just 29 percent of non-smokers finished their therapy, maybe because the bud helps lessen the treatment’s side effects.

Marijuana also appears to enhance the treatment’s efficacy: 54 percent of hep C sufferers smoking marijuana obtained their viral levels reduced and kept them reduced, compared to just 8 percent of nonsmokers.

Patients with inflammatory bowel diseases like Crohn’s disease and ulcerative disorders may benefit from marijuana usage, studies indicate.

University of Nottingham researchers discovered in 2010 that compounds in marijuana, such as THC and cannabidiol, interact with cells in the body which play a significant role in gut function and immune reactions. The analysis was published in the Journal of Pharmacology and Experimental Therapeutics.

The body creates THC-like chemicals that increase the permeability of the intestines, allowing bacteria inside. However, the cannabinoids in marijuana block those chemicals, which makes the cells bond together tighter and eventually become less permeable.

However, the National Academies report stated there isn’t enough evidence to make sure whether marijuana actually helps with those circumstances, so more study is required.

Researchers in rheumatology units at many hospital gave their patients Sativex, a cannabinoid-based pain-relieving medication. Following a two-week interval, individuals on Sativex experienced a substantial decrease in pain and improved sleep quality when compared with placebo users.

Other studies have found that plant-derived cannabinoids and inhaled marijuana may reduce arthritis pain, according to the National Academies report.

A study published in the American Journal Of Medicine indicated that marijuana smokers are more slender than the ordinary person and have healthy metabolism and response to sugars, despite the fact that they do wind up consuming more calories.

The study examined data from over 4,500 mature Americans — 579 of whom were current marijuana smokers, which means that they had smoked in the previous month. Approximately 2,000 people had used marijuana before, while another 2,000 hadn’t used the medication.

The researchers analyzed how the participants’ bodies reacted to sugars. They quantified blood-sugar levels and also the hormone insulin following participants hadn’t consumed in 2 hoursand after they’d consumed sugar.

Not only were marijuana users skinnier, their bodies had a much healthier reaction to sugar. Obviously, the analysis couldn’t ascertain if the marijuana users were similar to this to start with or if those traits were somehow associated with their smoking.

Getty Images / Marc Piscotty.

Unlike stoner stereotypes, marijuana use has in fact been demonstrated to possess some positive emotional consequences, especially concerning raising imagination, at least in certain contexts. Though people’s short lived memories often work worse if they’re large they really get better at tests requiring them to think of new thoughts.

Scientists also have discovered that some research participants enhance their "verbal fluency," their capacity to think of various words, when using marijuana.

Part of the increased creative capability may come in the release of dopamine in the brain, which lowers inhibitions and enables people to feel relaxed, giving the mind the capacity to perceive things differently.

Research in Israel indicates that smoking bud considerably reduces pain and tremors and enhances sleep for Parkinson’s disease sufferers. Particularly impressive has been the enhanced fine motor abilities among patients.

Medical marijuana is legal in Israel for numerous ailments, and also a great deal of research to the medical applications of cannabis is completed there, encouraged by the Israeli authorities.

In 2014the Colorado Department of Public Health awarded $2 million into the Multidisciplinary Association for Psychedelic Studies (among the greatest proponents of marijuana study ) to research marijuana’s possible for those who have post-traumatic anxiety disorder.

Naturally occurring cannabinoids, very similar to THC, help modulate the system which leads to fear and nervousness within the human body and mind.

Marijuana is approved to treat PTSD in certain countries currently — in New Mexico, PTSD is your number one motive for individuals to find a permit for medical marijuana.

However there are still questions regarding the security of using marijuana whilst experiencing PTSD, this study — that has taken some time to get off the floor — will hopefully assist response.

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Research in the University of Nottingham demonstrates that marijuana might help shield the brain from damage in the stroke by lowering the size of the region influenced by the stroke — at least in mice, rats, and monkeys.

This isn’t the only study which has shown neuroprotective effects of cannabis. Some research demonstrates that the plant might help to protect the brain following other kinds of brain injury.

Lester Grinspoon, a professor of psychiatry at Harvard and marijuana advocate, recently published an open letter to NFL Commissioner Roger Goodell. Inside, he explained the NFL should quit testing players for bud, which the team should start funding research to the plant’s capacity to protect the mind rather.

"Already, many physicians and researchers feel that marijuana has exceptionally powerful neuroprotective properties, an understanding based on both the clinical and laboratory information," Grinspoon wrote.

Goodell said he’d think about allowing athletes to use marijuana if medical investigation demonstrates that it’s a powerful neuroprotective agent.

At least one recent research on the subject discovered that individuals who had used marijuana were significantly less likely to die from traumatic brain injuries.

This is a complex one, since it entails effects which could be both negative and positive. Marijuana wreaks sleep cycles by disrupting the subsequent phases of REM sleep. In the long term, this might be troublesome for users.

But for individuals experiencing serious nightmares, particularly those connected with PTSD, this is sometimes helpful, maybe in the brief term. Nightmares and other fantasies happen during the very same phases of sleep. By disrupting REM sleep, a lot of these dreams might not happen. Research into having a synthetic cannabinoid — like THC but not exactly the same — revealed a substantial drop in the amount of nightmares in patients with PTSD.

In addition, even if regular use can be awful for sleep, bud might be a better sleeping aid than another materials that people use. A number of the, including alcohol and medication, might potentially have worse effects on sleep, even though more study is necessary on the subject.

Harrison Jacobs/Business Insider.

Among the most famous medical applications of marijuana would be for individuals experiencing chemotherapy. There’s great proof that it’s powerful for this, as stated by the National Academies report.

Cancer patients being treated with chemo suffer with debilitating nausea, vomiting, and lack of desire. This may result in further health complications.

Marijuana can help lessen these side effects, relieving pain, decreasing nausea, and stimulating the desire. Additionally, there are multiple FDA-approved cannabinoid medications which use THC, the key active compound in marijuana, for exactly the identical function.

Marijuana is safer than alcohol. This ‘s not to mention it’s secure, however cannabis is not as addictive than alcohol and also doesn’t cause almost as much physical harm.

Diseases like alcoholism include disruptions from the endocannabinoid system. Due to that, some people today believe cannabis may help patients struggling with these ailments.

Research published in the Harm Reduction Journal discovered that some people today use marijuana as a less dangerous substitute for alcohol, prescription medications, and other illegal drugs. One of the most common causes patients make that substitution are that marijuana has significantly less unwanted effects and is less likely to cause stomach issues.

Some individuals do become emotionally determined by marijuana, and it’s not a cure for chemical abuse issues. However from a harm-reduction perspective, it might help.

However it’s worth noting combining alcohol and marijuana can be harmful, and some investigators are worried that this situation is much more likely than one where users substitute a toke to get a beverage.

A man shops for bud in The Source dispensary, Saturday, July 1, 2017, at Las Vegas. Recreational marijuana became legal in Nevada on Saturday. John Locher/AP.

When there are lots of factors supporting the present opioid outbreak, many experts concur that using opioid painkillers to deal with chronic pain has played a significant role. It’s very insecure to take strong drugs which have a higher risk of inducing overdose and higher dependence prices. Pot, which could also cure chronic pain, is much less insecure.

Several studies have demonstrated that countries that permit medical marijuana possess fewer opioid deaths. This effect appears to rise over time, together with countries who pass those laws visiting a "20% reduced rate of opioid deaths at the legislation ‘ year, 24 percent at the third, and 33 percent at the sixth," based on Stat News.

It’s difficult to state deaths went down due to medical marijuana legalization rather than other explanations. But since the effect appears to have stronger the longer bud stays valid, researchers believe marijuana is a probable reason for the decrease in opioid deaths.